2021 Big 12 Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 5 | 145 | 1 | 1.25 |
| 1 | Baylor | 4 | 5 | 47 | 0 | 1.25 |
| 3 | Iowa State | 4 | 4 | 42 | 1 | 1.00 |
| 3 | Texas | 4 | 4 | 40 | 0 | 1.00 |
| 5 | West Virginia | 4 | 3 | 76 | 0 | 0.75 |
| 5 | TCU | 5 | 3 | 29 | 1 | 0.60 |
| 7 | Kansas | 4 | 2 | 22 | 0 | 0.50 |
| 7 | Kansas State | 4 | 2 | 10 | 0 | 0.50 |
| 7 | Oklahoma | 5 | 2 | 23 | 0 | 0.40 |
| 10 | Texas Tech | 5 | 1 | 9 | 0 | 0.20 |