2021 Atlantic Coast Conference Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Malik Cunningham | Louisville | JR | QB | 1 | 66 | 207 | 33 | 273 | 8.27 | 273.0 |
| 2 | Sam Howell | N Carolina | JR | QB | 1 | 3 | 205 | 33 | 208 | 6.30 | 208.0 |
| 3 | Sam Hartman | Wk Forest | SO | QB | 2 | 21 | 517 | 102 | 538 | 5.27 | 269.0 |
| 4 | DJ Uiagalelei | Clemson | SO | QB | 1 | 12 | 187 | 38 | 199 | 5.24 | 199.0 |
| 5 | Trevion Cooley | Louisville | FR | RB | 1 | 92 | 0 | 18 | 92 | 5.11 | 92.0 |
| 6 | Kobe Pace | Clemson | SO | RB | 1 | 51 | 0 | 12 | 51 | 4.25 | 51.0 |
| 7 | Tahj Bullock | Va Tech | FR | QB | 1 | 14 | 27 | 10 | 41 | 4.10 | 41.0 |
| 8 | Connor Blumrick | Va Tech | JR | QB | 1 | 11 | 110 | 30 | 121 | 4.03 | 121.0 |
| 9 | Raheem Blackshear | Va Tech | JR | RB | 1 | 46 | 0 | 12 | 46 | 3.83 | 46.0 |
| 10 | Vincent Davis | Pittsburgh | JR | RB | 2 | 82 | 0 | 23 | 82 | 3.57 | 41.0 |
| 11 | Will Shipley | Clemson | FR | RB | 1 | 61 | 0 | 18 | 61 | 3.39 | 61.0 |
| 12 | Ty Chandler | N Carolina | SR | RB | 1 | 29 | 0 | 9 | 29 | 3.22 | 29.0 |
| 13 | Christian Beal-Smith | Wk Forest | JR | RB | 2 | 47 | 0 | 18 | 47 | 2.61 | 23.5 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.