2021 Atlantic Coast Conference Leaders Sacks - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Luiji Vilain | Wk Forest | SR | DL | 2 | 2.0 | 24 | 1.00 |
| 1 | SirVocea Dennis | Pittsburgh | JR | LB | 2 | 2.0 | 16 | 1.00 |
| 3 | Jasheen Davis | Wk Forest | FR | DL | 2 | 1.5 | 9 | 0.75 |
| 4 | Keyshon Camp | Pittsburgh | SR | DL | 1 | 1.0 | 12 | 1.00 |
| 4 | Bam Brima | Pittsburgh | SO | DL | 2 | 1.0 | 10 | 0.50 |
| 4 | Dion Bergan, Jr. | Wk Forest | JR | DL | 2 | 1.0 | 10 | 0.50 |
| 4 | Tomon Fox | N Carolina | SR | LB | 1 | 1.0 | 9 | 1.00 |
| 4 | Cedric Gray | N Carolina | SO | LB | 1 | 1.0 | 9 | 1.00 |
| 4 | Tyler Bentley | Pittsburgh | JR | DL | 2 | 1.0 | 8 | 0.50 |
| 4 | Ashton Gillotte | Louisville | FR | DL | 1 | 1.0 | 6 | 1.00 |
| 4 | Yasir Abdullah | Louisville | JR | LB | 1 | 1.0 | 6 | 1.00 |
| 4 | Devin Danielson | Pittsburgh | JR | DL | 2 | 1.0 | 6 | 0.50 |
| 4 | K.J. Henry | Clemson | JR | DE | 1 | 1.0 | 5 | 1.00 |
| 4 | Dayon Hayes | Pittsburgh | SO | DL | 2 | 1.0 | 4 | 0.50 |
| 4 | Rondell Bothroyd | Wk Forest | SO | DL | 2 | 1.0 | 4 | 0.50 |
| 4 | Habakkuk Baldonado | Pittsburgh | JR | DL | 2 | 1.0 | 3 | 0.50 |
| 17 | Chase Jones | Wk Forest | SO | LB | 2 | 0.5 | 7 | 0.25 |