2021 Atlantic Coast Conference Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | A.J. Woods | Pittsburgh | JR | DB | 2 | 1 | 2 | 3 | 1.50 |
| 1 | Damarri Mathis | Pittsburgh | SR | DB | 1 | 0 | 2 | 2 | 2.00 |
| 1 | M.J. Devonshire | Pittsburgh | SO | DB | 2 | 0 | 2 | 2 | 1.00 |
| 4 | Erick Hallett II | Pittsburgh | JR | DB | 2 | 2 | 1 | 3 | 1.50 |
| 4 | Mario Goodrich | Clemson | SR | CB | 1 | 1 | 1 | 2 | 2.00 |
| 4 | Marquis Williams | Pittsburgh | JR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 4 | Gavin Holmes | Wk Forest | FR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 4 | Zion Keith | Wk Forest | SO | DB | 2 | 1 | 1 | 2 | 1.00 |
| 4 | Jalyn Phillips | Clemson | JR | S | 1 | 0 | 1 | 1 | 1.00 |
| 4 | Justin Mascoll | Clemson | JR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 4 | Ruke Orhorhoro | Clemson | SO | DT | 1 | 0 | 1 | 1 | 1.00 |
| 4 | Trey Morrison | N Carolina | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 4 | Ryan Smenda, Jr. | Wk Forest | JR | LB | 2 | 0 | 1 | 1 | 0.50 |
| 4 | Dion Bergan, Jr. | Wk Forest | JR | DL | 2 | 0 | 1 | 1 | 0.50 |
| 4 | Malik Mustapha | Wk Forest | FR | DB | 2 | 0 | 1 | 1 | 0.50 |
| 4 | Nick Andersen | Wk Forest | FR | DB | 2 | 0 | 1 | 1 | 0.50 |