2021 Atlantic Coast Conference Leaders Rushing Defense - All Games through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 12 | 391 | 1479 | 3.78 | 9 | 32.58 | 123.25 |
| 2 | Miami (Florida) | 12 | 429 | 1668 | 3.89 | 16 | 35.75 | 139.00 |
| 3 | Syracuse | 12 | 438 | 1513 | 3.45 | 12 | 36.50 | 126.08 |
| 4 | Clemson | 13 | 440 | 1252 | 2.85 | 7 | 33.85 | 96.31 |
| 5 | Boston College | 12 | 451 | 2043 | 4.53 | 15 | 37.58 | 170.25 |
| 6 | Louisville | 13 | 467 | 2037 | 4.36 | 23 | 35.92 | 156.69 |
| 7 | Duke | 12 | 468 | 2470 | 5.28 | 26 | 39.00 | 205.83 |
| 7 | Virginia | 12 | 468 | 2710 | 5.79 | 21 | 39.00 | 225.83 |
| 9 | Pittsburgh | 14 | 472 | 1249 | 2.65 | 15 | 33.71 | 89.21 |
| 10 | Florida State | 12 | 477 | 1735 | 3.64 | 15 | 39.75 | 144.58 |
| 11 | Virginia Tech | 13 | 481 | 2198 | 4.57 | 20 | 37.00 | 169.08 |
| 12 | Georgia Tech | 12 | 491 | 2184 | 4.45 | 19 | 40.92 | 182.00 |
| 13 | North Carolina | 13 | 504 | 2340 | 4.64 | 23 | 38.77 | 180.00 |
| 14 | Wake Forest | 14 | 563 | 2738 | 4.86 | 25 | 40.21 | 195.57 |