2021 Atlantic Coast Conference Leaders Total Defense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 3 | 431 | 675 | 239 | 1106 | 4.63 | 368.7 |
| 2 | Wake Forest | 3 | 775 | 699 | 224 | 1474 | 6.58 | 491.3 |
| 3 | North Carolina State | 3 | 233 | 909 | 226 | 1142 | 5.05 | 380.7 |
| 4 | Boston College | 6 | 1276 | 1117 | 402 | 2393 | 5.95 | 398.8 |
| 5 | Pittsburgh | 3 | 280 | 1137 | 242 | 1417 | 5.86 | 472.3 |
| 6 | Miami (Florida) | 5 | 909 | 1311 | 376 | 2220 | 5.90 | 444.0 |
| 7 | North Carolina | 7 | 1431 | 1512 | 448 | 2943 | 6.57 | 420.4 |
| 8 | Syracuse | 7 | 891 | 1535 | 461 | 2426 | 5.26 | 346.6 |
| 9 | Virginia | 6 | 1718 | 1584 | 429 | 3302 | 7.70 | 550.3 |
| 10 | Virginia Tech | 7 | 1376 | 1597 | 472 | 2973 | 6.30 | 424.7 |
| 11 | Florida State | 7 | 942 | 1852 | 537 | 2794 | 5.20 | 399.1 |
| 12 | Louisville | 7 | 1088 | 2117 | 498 | 3205 | 6.44 | 457.9 |
| 13 | Georgia Tech | 9 | 1770 | 2567 | 598 | 4337 | 7.25 | 481.9 |
| 14 | Duke | 9 | 1898 | 3102 | 661 | 5000 | 7.56 | 555.6 |