2021 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 2 | 219 | 401 | 140 | 620 | 4.43 | 310.0 |
| 2 | Virginia Tech | 2 | 388 | 424 | 150 | 812 | 5.41 | 406.0 |
| 3 | Duke | 2 | 486 | 827 | 169 | 1313 | 7.77 | 656.5 |
| 4 | Boston College | 3 | 538 | 694 | 212 | 1232 | 5.81 | 410.7 |
| 5 | Wake Forest | 3 | 519 | 891 | 223 | 1410 | 6.32 | 470.0 |
| 6 | Pittsburgh | 3 | 302 | 718 | 233 | 1020 | 4.38 | 340.0 |
| 7 | Georgia Tech | 4 | 759 | 1082 | 254 | 1841 | 7.25 | 460.3 |
| 8 | Syracuse | 4 | 431 | 1040 | 268 | 1471 | 5.49 | 367.8 |
| 9 | Miami (Florida) | 4 | 519 | 1444 | 292 | 1963 | 6.72 | 490.8 |
| 10 | North Carolina | 4 | 721 | 1221 | 294 | 1942 | 6.61 | 485.5 |
| 11 | Virginia | 4 | 1006 | 1133 | 298 | 2139 | 7.18 | 534.8 |
| 12 | Florida State | 4 | 564 | 1128 | 302 | 1692 | 5.60 | 423.0 |
| 13 | Clemson | 4 | 467 | 1045 | 314 | 1512 | 4.82 | 378.0 |
| 14 | Louisville | 5 | 896 | 1391 | 352 | 2287 | 6.50 | 457.4 |