2021 Atlantic Coast Conference Leaders Passing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 11 | 312 | 179 | 57.4 | 2158 | 6.9 | 16 | 12 | 124.70 | 28.4 | 196.2 |
| 2 | North Carolina State | 10 | 340 | 185 | 54.4 | 2090 | 6.1 | 14 | 11 | 113.16 | 34.0 | 209.0 |
| 3 | Clemson | 9 | 296 | 152 | 51.4 | 1674 | 5.7 | 4 | 10 | 96.55 | 32.9 | 186.0 |
| 3 | Florida State | 8 | 268 | 143 | 53.4 | 1670 | 6.2 | 14 | 10 | 115.48 | 33.5 | 208.8 |
| 5 | Boston College | 9 | 225 | 130 | 57.8 | 1388 | 6.2 | 8 | 9 | 113.33 | 25.0 | 154.2 |
| 5 | Louisville | 8 | 273 | 178 | 65.2 | 1789 | 6.6 | 11 | 9 | 126.96 | 34.1 | 223.6 |
| 5 | Pittsburgh | 11 | 378 | 237 | 62.7 | 2982 | 7.9 | 21 | 9 | 142.54 | 34.4 | 271.1 |
| 8 | North Carolina | 9 | 232 | 147 | 63.4 | 1873 | 8.1 | 13 | 8 | 142.76 | 25.8 | 208.1 |
| 8 | Virginia Tech | 11 | 329 | 195 | 59.3 | 2490 | 7.6 | 16 | 8 | 134.03 | 29.9 | 226.4 |
| 8 | Duke | 10 | 320 | 188 | 58.8 | 2914 | 9.1 | 26 | 8 | 157.05 | 32.0 | 291.4 |
| 11 | Miami (Florida) | 8 | 268 | 161 | 60.1 | 1563 | 5.8 | 8 | 6 | 114.44 | 33.5 | 195.4 |
| 12 | Virginia | 8 | 245 | 142 | 58.0 | 1749 | 7.1 | 13 | 5 | 131.36 | 30.6 | 218.6 |
| 13 | Georgia Tech | 8 | 227 | 145 | 63.9 | 2194 | 9.7 | 18 | 3 | 168.60 | 28.4 | 274.3 |
| 14 | Syracuse | 8 | 208 | 137 | 65.9 | 1411 | 6.8 | 12 | 2 | 139.98 | 26.0 | 176.4 |