2021 Atlantic Coast Conference Leaders First Downs - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 6 | 45 | 82 | 14 | 141 | 23.5 |
| 2 | Virginia | 5 | 39 | 79 | 8 | 126 | 25.2 |
| 3 | North Carolina | 7 | 74 | 71 | 17 | 162 | 23.1 |
| 4 | Louisville | 7 | 65 | 70 | 13 | 148 | 21.1 |
| 5 | Miami (Florida) | 5 | 35 | 64 | 18 | 117 | 23.4 |
| 6 | Wake Forest | 4 | 20 | 63 | 14 | 97 | 24.3 |
| 7 | North Carolina State | 4 | 23 | 58 | 9 | 90 | 22.5 |
| 8 | Florida State | 5 | 33 | 47 | 9 | 89 | 17.8 |
| 8 | Georgia Tech | 6 | 44 | 47 | 10 | 101 | 16.8 |
| 10 | Clemson | 6 | 49 | 45 | 11 | 105 | 17.5 |
| 11 | Virginia Tech | 5 | 44 | 37 | 8 | 89 | 17.8 |
| 12 | Syracuse | 5 | 55 | 36 | 12 | 103 | 20.6 |
| 13 | Duke | 3 | 23 | 26 | 4 | 53 | 17.7 |
| 14 | Boston College | 3 | 19 | 20 | 6 | 45 | 15.0 |