2021 Atlantic Coast Conference Leaders Rushing Offense - Games Lost Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 7 | 276 | 1410 | 5.11 | 13 | 39.43 | 201.43 |
| 2 | North Carolina | 7 | 248 | 1178 | 4.75 | 9 | 35.43 | 168.29 |
| 3 | Georgia Tech | 9 | 326 | 1466 | 4.50 | 9 | 36.22 | 162.89 |
| 4 | Syracuse | 7 | 260 | 1158 | 4.45 | 10 | 37.14 | 165.43 |
| 5 | Florida State | 7 | 244 | 1008 | 4.13 | 9 | 34.86 | 144.00 |
| 6 | Duke | 9 | 381 | 1526 | 4.01 | 8 | 42.33 | 169.56 |
| 7 | Virginia Tech | 7 | 276 | 1094 | 3.96 | 7 | 39.43 | 156.29 |
| 8 | Clemson | 3 | 76 | 269 | 3.54 | 3 | 25.33 | 89.67 |
| 9 | Virginia | 6 | 151 | 526 | 3.48 | 8 | 25.17 | 87.67 |
| 10 | North Carolina State | 3 | 65 | 219 | 3.37 | 1 | 21.67 | 73.00 |
| 11 | Miami (Florida) | 5 | 152 | 508 | 3.34 | 6 | 30.40 | 101.60 |
| 12 | Pittsburgh | 3 | 79 | 247 | 3.13 | 2 | 26.33 | 82.33 |
| 13 | Wake Forest | 3 | 109 | 335 | 3.07 | 5 | 36.33 | 111.67 |
| 14 | Boston College | 6 | 220 | 660 | 3.00 | 4 | 36.67 | 110.00 |