2021 Atlantic Coast Conference Leaders Passes Defended - Games Lost Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 7 | 7 | 21 | 28 | 4.00 |
| 2 | Virginia | 6 | 4 | 22 | 26 | 4.33 |
| 2 | Virginia Tech | 7 | 4 | 22 | 26 | 3.71 |
| 4 | Duke | 9 | 3 | 35 | 38 | 4.22 |
| 4 | Louisville | 7 | 3 | 26 | 29 | 4.14 |
| 4 | Boston College | 6 | 3 | 16 | 19 | 3.17 |
| 4 | Syracuse | 7 | 3 | 16 | 19 | 2.71 |
| 4 | North Carolina State | 3 | 3 | 9 | 12 | 4.00 |
| 9 | North Carolina | 7 | 2 | 21 | 23 | 3.29 |
| 9 | Miami (Florida) | 5 | 2 | 10 | 12 | 2.40 |
| 9 | Pittsburgh | 3 | 2 | 8 | 10 | 3.33 |
| 12 | Clemson | 3 | 1 | 9 | 10 | 3.33 |
| 12 | Wake Forest | 3 | 1 | 7 | 8 | 2.67 |
| 14 | Georgia Tech | 9 | 0 | 18 | 18 | 2.00 |