2021 Atlantic Coast Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 4 | 431 | 1462 | 289 | 1893 | 6.55 | 473.3 |
| 2 | Miami (Florida) | 4 | 298 | 1318 | 288 | 1616 | 5.61 | 404.0 |
| 3 | Louisville | 5 | 945 | 1110 | 346 | 2055 | 5.94 | 411.0 |
| 4 | North Carolina | 4 | 942 | 1000 | 289 | 1942 | 6.72 | 485.5 |
| 5 | Wake Forest | 3 | 234 | 873 | 251 | 1107 | 4.41 | 369.0 |
| 6 | Florida State | 4 | 459 | 813 | 252 | 1272 | 5.05 | 318.0 |
| 7 | Pittsburgh | 3 | 378 | 745 | 209 | 1123 | 5.37 | 374.3 |
| 8 | Georgia Tech | 4 | 394 | 731 | 250 | 1125 | 4.50 | 281.3 |
| 9 | Clemson | 4 | 602 | 650 | 245 | 1252 | 5.11 | 313.0 |
| 10 | North Carolina State | 2 | 222 | 646 | 173 | 868 | 5.02 | 434.0 |
| 11 | Syracuse | 4 | 714 | 634 | 260 | 1348 | 5.18 | 337.0 |
| 12 | Boston College | 3 | 294 | 524 | 184 | 818 | 4.45 | 272.7 |
| 13 | Duke | 2 | 295 | 396 | 150 | 691 | 4.61 | 345.5 |
| 14 | Virginia Tech | 2 | 217 | 321 | 131 | 538 | 4.11 | 269.0 |