2021 Atlantic Coast Conference Leaders Rushing Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 11 | 451 | 2013 | 4.46 | 25 | 41.00 | 183.00 |
| 2 | Syracuse | 8 | 340 | 1848 | 5.44 | 22 | 42.50 | 231.00 |
| 2 | Pittsburgh | 11 | 412 | 1711 | 4.15 | 22 | 37.45 | 155.55 |
| 4 | Duke | 10 | 436 | 1871 | 4.29 | 21 | 43.60 | 187.10 |
| 5 | Louisville | 8 | 307 | 1823 | 5.94 | 20 | 38.38 | 227.88 |
| 5 | Boston College | 9 | 386 | 1677 | 4.34 | 20 | 42.89 | 186.33 |
| 7 | Clemson | 9 | 359 | 1582 | 4.41 | 19 | 39.89 | 175.78 |
| 8 | North Carolina | 9 | 342 | 1826 | 5.34 | 18 | 38.00 | 202.89 |
| 8 | Miami (Florida) | 8 | 293 | 1234 | 4.21 | 18 | 36.63 | 154.25 |
| 10 | Florida State | 8 | 308 | 1673 | 5.43 | 17 | 38.50 | 209.13 |
| 11 | Virginia | 8 | 233 | 1054 | 4.52 | 16 | 29.13 | 131.75 |
| 12 | Georgia Tech | 8 | 305 | 1633 | 5.35 | 14 | 38.13 | 204.13 |
| 12 | Virginia Tech | 11 | 467 | 2188 | 4.69 | 14 | 42.45 | 198.91 |
| 14 | North Carolina State | 10 | 303 | 1292 | 4.26 | 11 | 30.30 | 129.20 |