2021 American Athletic Conference Leaders Rushing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jaren Mangham | S Florida | JR | RB | 4 | 55 | 189 | 3.44 | 4 | 13.75 | 47.25 |
| 2 | Jerome Ford | Cincinnati | JR | RB | 3 | 50 | 335 | 6.70 | 2 | 16.67 | 111.67 |
| 2 | Tre Siggers | SMU | SR | RB | 2 | 23 | 108 | 4.70 | 2 | 11.50 | 54.00 |
| 2 | Tyjae Spears | Tulane | FR | RB | 4 | 36 | 206 | 5.72 | 2 | 9.00 | 51.50 |
| 2 | Timmy McClain | S Florida | FR | QB | 4 | 39 | 130 | 3.33 | 2 | 9.75 | 32.50 |
| 2 | Tai Lavatai | Navy | SO | QB | 2 | 30 | 15 | 0.50 | 2 | 15.00 | 7.50 |
| 7 | Isaac Ruoss | Navy | SR | FB | 3 | 55 | 208 | 3.78 | 1 | 18.33 | 69.33 |
| 7 | Cameron Carroll | Tulane | SO | RB | 4 | 42 | 203 | 4.83 | 1 | 10.50 | 50.75 |
| 7 | Anthony Watkins | Tulsa | SO | RB | 4 | 31 | 197 | 6.35 | 1 | 7.75 | 49.25 |
| 7 | Shamari Brooks | Tulsa | SR | RB | 4 | 53 | 187 | 3.53 | 1 | 13.25 | 46.75 |
| 7 | Deneric Prince | Tulsa | JR | RB | 2 | 25 | 72 | 2.88 | 1 | 12.50 | 36.00 |
| 7 | Xavier Arline | Navy | SO | QB | 2 | 27 | 72 | 2.67 | 1 | 13.50 | 36.00 |
| 7 | Isaiah Bowser | UCF | SR | RB | 1 | 13 | 27 | 2.08 | 1 | 13.00 | 27.00 |
| 7 | Edward Saydee | Temple | FR | RB | 2 | 13 | 46 | 3.54 | 1 | 6.50 | 23.00 |
| 7 | Desmond Ridder | Cincinnati | SR | QB | 3 | 27 | 39 | 1.44 | 1 | 9.00 | 13.00 |
| 7 | Brian Battie | S Florida | SO | RB | 4 | 13 | 36 | 2.77 | 1 | 3.25 | 9.00 |
| 7 | Jaetavian Toles | Tulane | SR | WR | 4 | 5 | 24 | 4.80 | 1 | 1.25 | 6.00 |
| 7 | Michael Pratt | Tulane | FR | QB | 4 | 42 | 23 | 0.55 | 1 | 10.50 | 5.75 |
| 7 | Mark-Antony Richards | UCF | SO | RB | 1 | 1 | 2 | 2.00 | 1 | 1.00 | 2.00 |
| 7 | Xavier Weaver | S Florida | JR | WR | 4 | 1 | 3 | 3.00 | 1 | 0.25 | 0.75 |
| 7 | Holton Ahlers | ECU | JR | QB | 2 | 19 | -22 | -1.16 | 1 | 9.50 | -11.00 |