2021 American Athletic Conference Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Davonte Brown | UCF | SO | DB | 1 | 0 | 3 | 3 | 3.00 |
| 2 | Bryan Cook | Cincinnati | SR | S | 2 | 1 | 2 | 3 | 1.50 |
| 2 | Michael McMorris | Navy | SR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 2 | Damarion Williams | Houston | SR | CB | 2 | 0 | 2 | 2 | 1.00 |
| 5 | Joel Dublanko | Cincinnati | SR | LB | 2 | 1 | 1 | 2 | 1.00 |
| 5 | Quadric Bullard | UCF | SO | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Justin Hodges | UCF | SO | DB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Jeremiah Jean-Baptiste | UCF | JR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Marcus Jones | Houston | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Cristian Williams | Tulsa | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Treyvon Reeves | Tulsa | SR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Tyon Davis | Tulsa | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Eavan Gibbons | Navy | SO | BAN | 1 | 0 | 1 | 1 | 1.00 |
| 5 | John Marshall | Navy | JR | STR | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Rayuan Lane | Navy | FR | S | 1 | 0 | 1 | 1 | 1.00 |
| 5 | Myjai Sanders | Cincinnati | SR | DL | 2 | 0 | 1 | 1 | 0.50 |