2021 American Athletic Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Turner Coxe | SMU | SR | LB | 1 | 2.0 | 14 | 2.00 |
| 1 | Darrian Beavers | Cincinnati | SR | LB | 2 | 2.0 | 12 | 1.00 |
| 1 | Cullen Wick | Tulsa | SR | DL | 2 | 2.0 | 11 | 1.00 |
| 4 | JoJo Dorceus | Tulane | SR | DL | 2 | 1.5 | 19 | 0.75 |
| 5 | Anthony Goodlow | Tulsa | JR | DL | 2 | 1.0 | 10 | 0.50 |
| 5 | Maurice White | Memphis | SR | DL | 1 | 1.0 | 9 | 1.00 |
| 5 | Josh Celiscar | UCF | SO | DL | 2 | 1.0 | 9 | 0.50 |
| 5 | Jeremy Lewis | ECU | SO | OLB | 1 | 1.0 | 8 | 1.00 |
| 5 | Rick D'Abreu | ECU | SO | DL | 1 | 1.0 | 8 | 1.00 |
| 5 | Blake Green | S Florida | SR | DT | 2 | 1.0 | 8 | 0.50 |
| 5 | Manny Walker | Temple | SR | DE | 2 | 1.0 | 8 | 0.50 |
| 5 | Darius Hodges | Tulane | FR | JOK | 2 | 1.0 | 8 | 0.50 |
| 5 | D'Anthony Jones | Houston | JR | DL | 1 | 1.0 | 7 | 1.00 |
| 5 | Derek Parish | Houston | JR | DL | 2 | 1.0 | 7 | 0.50 |
| 5 | David Anenih | Houston | SR | DL | 2 | 1.0 | 7 | 0.50 |
| 5 | Antonio Grier | S Florida | SR | LB | 2 | 1.0 | 7 | 0.50 |
| 5 | Kendarin Ray | Tulsa | JR | S | 2 | 1.0 | 7 | 0.50 |
| 5 | Jeremiah Jean-Baptiste | UCF | JR | LB | 2 | 1.0 | 2 | 0.50 |
| 5 | Wilson Huber | Cincinnati | SR | LB | 2 | 1.0 | 2 | 0.50 |
| 5 | Cam Goode | UCF | JR | DL | 2 | 1.0 | 1 | 0.50 |
| 21 | Sedrick Williams | Houston | JR | DL | 2 | 0.5 | 5 | 0.25 |
| 21 | Noah Seiden | Tulane | SO | DE | 2 | 0.5 | 5 | 0.25 |
| 21 | Xavier Smith | ECU | JR | ILB | 1 | 0.5 | 4 | 0.50 |
| 21 | Malik Robinson | Houston | JR | LB | 2 | 0.5 | 4 | 0.25 |
| 21 | Bruce Bivens | ECU | SR | ILB | 1 | 0.5 | 3 | 0.50 |
| 21 | Jaylon Allen | Memphis | JR | DL | 1 | 0.5 | 3 | 0.50 |
| 21 | John Tate IV | Memphis | SR | DL | 1 | 0.5 | 2 | 0.50 |