2021 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Navy | 2 | 14 | 11 | 1 | 26 | 13.0 |
| 2 | Tulane | 2 | 18 | 22 | 2 | 42 | 21.0 |
| 3 | South Florida | 3 | 24 | 28 | 1 | 53 | 17.7 |
| 4 | East Carolina | 5 | 43 | 35 | 4 | 82 | 16.4 |
| 5 | Cincinnati | 5 | 47 | 38 | 9 | 94 | 18.8 |
| 6 | Memphis | 4 | 44 | 51 | 7 | 102 | 25.5 |
| 7 | Tulsa | 7 | 45 | 63 | 14 | 122 | 17.4 |
| 8 | Houston | 8 | 55 | 64 | 17 | 136 | 17.0 |
| 9 | Temple | 6 | 88 | 45 | 8 | 141 | 23.5 |
| 10 | SMU | 7 | 46 | 83 | 13 | 142 | 20.3 |
| 11 | UCF | 8 | 71 | 73 | 15 | 159 | 19.9 |