2021 American Athletic Conference Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 8 | 31 | 7 | 29 | 0 | 0 | 236 | 29.5 |
| 2 | Navy | 9 | 32 | 8 | 30 | 1 | 1 | 250 | 27.8 |
| 2 | South Florida | 8 | 31 | 8 | 27 | 0 | 0 | 237 | 29.6 |
| 4 | Cincinnati | 11 | 21 | 9 | 19 | 1 | 1 | 176 | 16.0 |
| 4 | East Carolina | 10 | 32 | 9 | 26 | 2 | 0 | 249 | 24.9 |
| 6 | SMU | 10 | 32 | 10 | 27 | 0 | 0 | 249 | 24.9 |
| 6 | Temple | 10 | 47 | 10 | 45 | 1 | 1 | 361 | 36.1 |
| 8 | Houston | 13 | 31 | 11 | 28 | 2 | 0 | 251 | 19.3 |
| 9 | UCF | 12 | 32 | 13 | 32 | 0 | 0 | 263 | 21.9 |
| 10 | Tulsa | 9 | 23 | 14 | 20 | 2 | 0 | 204 | 22.7 |
| 10 | Memphis | 11 | 40 | 14 | 36 | 1 | 0 | 320 | 29.1 |