2021 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Tulane | 9 | 75 | 107 | 11 | 193 | 21.4 |
| 1 | South Florida | 9 | 89 | 111 | 11 | 211 | 23.4 |
| 3 | East Carolina | 10 | 81 | 90 | 12 | 183 | 18.3 |
| 4 | Memphis | 10 | 114 | 109 | 13 | 236 | 23.6 |
| 5 | Navy | 12 | 86 | 105 | 14 | 205 | 17.1 |
| 5 | Temple | 9 | 116 | 95 | 14 | 225 | 25.0 |
| 7 | Tulsa | 10 | 67 | 99 | 19 | 185 | 18.5 |
| 7 | SMU | 10 | 69 | 118 | 19 | 206 | 20.6 |
| 7 | UCF | 10 | 93 | 101 | 19 | 213 | 21.3 |
| 10 | Cincinnati | 11 | 94 | 91 | 21 | 206 | 18.7 |
| 11 | Houston | 11 | 66 | 94 | 25 | 185 | 16.8 |