2021 American Athletic Conference Leaders Rushing Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 3 | 177 | 560 | 3.16 | 4 | 59.00 | 186.67 |
| 2 | Houston | 1 | 47 | 86 | 1.83 | 0 | 47.00 | 86.00 |
| 3 | Tulane | 4 | 153 | 520 | 3.40 | 5 | 38.25 | 130.00 |
| 4 | Tulsa | 4 | 152 | 524 | 3.45 | 3 | 38.00 | 131.00 |
| 5 | UCF | 1 | 37 | 155 | 4.19 | 2 | 37.00 | 155.00 |
| 6 | East Carolina | 2 | 73 | 136 | 1.86 | 1 | 36.50 | 68.00 |
| 7 | South Florida | 4 | 145 | 489 | 3.37 | 8 | 36.25 | 122.25 |
| 8 | Cincinnati | 3 | 84 | 377 | 4.49 | 3 | 28.00 | 125.67 |
| 8 | Memphis | 1 | 28 | 106 | 3.79 | 0 | 28.00 | 106.00 |
| 10 | SMU | 2 | 55 | 183 | 3.33 | 2 | 27.50 | 91.50 |
| 11 | Temple | 2 | 52 | 183 | 3.52 | 1 | 26.00 | 91.50 |