2021 American Athletic Conference Leaders Passing Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 1 | 26 | 17 | 65.4 | 250 | 9.6 | 2 | 1 | 163.85 | 26.0 | 250.0 |
| 2 | Cincinnati | 3 | 81 | 47 | 58.0 | 631 | 7.8 | 5 | 0 | 143.84 | 27.0 | 210.3 |
| 3 | Tulane | 4 | 112 | 66 | 58.9 | 769 | 6.9 | 7 | 2 | 133.66 | 28.0 | 192.3 |
| 4 | SMU | 2 | 63 | 39 | 61.9 | 371 | 5.9 | 4 | 1 | 129.16 | 31.5 | 185.5 |
| 5 | Tulsa | 4 | 147 | 88 | 59.9 | 1070 | 7.3 | 4 | 5 | 123.18 | 36.8 | 267.5 |
| 6 | East Carolina | 2 | 76 | 43 | 56.6 | 506 | 6.7 | 3 | 1 | 122.91 | 38.0 | 253.0 |
| 7 | Navy | 3 | 28 | 16 | 57.1 | 232 | 8.3 | 0 | 1 | 119.60 | 9.3 | 77.3 |
| 8 | South Florida | 4 | 133 | 69 | 51.9 | 887 | 6.7 | 3 | 7 | 104.81 | 33.3 | 221.8 |
| 9 | UCF | 1 | 27 | 16 | 59.3 | 141 | 5.2 | 1 | 2 | 100.53 | 27.0 | 141.0 |
| 10 | Memphis | 1 | 46 | 22 | 47.8 | 216 | 4.7 | 1 | 2 | 85.75 | 46.0 | 216.0 |
| 11 | Temple | 2 | 57 | 29 | 50.9 | 269 | 4.7 | 0 | 4 | 76.48 | 28.5 | 134.5 |