2021 American Athletic Conference Leaders Turnover Margin - Games in August/September Only through 01/10/2022
| Name | G | Fum. Gain | Int. Gain | Total Gain | Fum. Lost | Int. Lost | Total Lost | Margin | Margin/G | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 3 | 0 | 3 | 3 | 0 | 3 | 3 | 0 | 0.00 |
| 2 | Navy | 3 | 1 | 2 | 3 | 2 | 2 | 4 | -1 | -0.33 |
| 3 | Houston | 4 | 3 | 3 | 6 | 0 | 5 | 5 | 1 | 0.25 |
| 3 | Memphis | 4 | 2 | 1 | 3 | 4 | 1 | 5 | -2 | -0.50 |
| 5 | Cincinnati | 3 | 3 | 6 | 9 | 3 | 3 | 6 | 3 | 1.00 |
| 5 | Tulsa | 4 | 2 | 3 | 5 | 1 | 5 | 6 | -1 | -0.25 |
| 5 | South Florida | 4 | 1 | 3 | 4 | 2 | 4 | 6 | -2 | -0.50 |
| 5 | Temple | 4 | 1 | 3 | 4 | 4 | 2 | 6 | -2 | -0.50 |
| 9 | East Carolina | 4 | 3 | 5 | 8 | 2 | 5 | 7 | 1 | 0.25 |
| 9 | SMU | 4 | 2 | 6 | 8 | 2 | 5 | 7 | 1 | 0.25 |
| 11 | Tulane | 4 | 3 | 5 | 8 | 6 | 4 | 10 | -2 | -0.50 |