2021 American Athletic Conference Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 1 | 19 | 10 | 0 | 29 | 29.0 |
| 2 | Tulsa | 2 | 11 | 26 | 6 | 43 | 21.5 |
| 3 | UCF | 2 | 22 | 16 | 4 | 42 | 21.0 |
| 4 | Tulane | 2 | 15 | 20 | 3 | 38 | 19.0 |
| 5 | South Florida | 2 | 15 | 15 | 5 | 35 | 17.5 |
| 6 | Cincinnati | 2 | 16 | 15 | 3 | 34 | 17.0 |
| 6 | Houston | 2 | 13 | 19 | 2 | 34 | 17.0 |
| 8 | Temple | 2 | 11 | 12 | 2 | 25 | 12.5 |
| 9 | East Carolina | 1 | 6 | 5 | 1 | 12 | 12.0 |
| 9 | Memphis | 1 | 5 | 6 | 1 | 12 | 12.0 |