2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. Non-Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jayden Reed | Mich St | JR | WR | 4 | 8 | 5 | 3 | 3 | 3 | 2 | 0 |
| 2 | Broc Thompson | Purdue | JR | WR | 4 | 3 | 2 | 2 | 2 | 2 | 0 | 0 |
| 3 | AJ Barner | Indiana | SO | TE | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Ronnie Bell | Michigan | SR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Chase Brown | Illinois | SO | RB | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Blake Corum | Michigan | SO | RB | 4 | 4 | 3 | 3 | 2 | 1 | 0 | 0 |
| 3 | Emeka Egbuka | Ohio State | FR | WR | 4 | 5 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Isaac Guerendo | Wisconsin | JR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Cal Haladay | Mich St | FR | LB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | A.J. Henning | Michigan | SO | WR | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Jacolby Hewitt | Indiana | JR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Evan Hull | N'western | SO | RB | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Cornelius Johnson | Michigan | JR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Darryl Jones | Maryland | SR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | KeAndre Lambert-Smith | Penn State | SO | WR | 4 | 3 | 2 | 1 | 1 | 1 | 1 | 0 |
| 3 | Adrian Martinez | Nebraska | JR | QB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | D.J. Matthews Jr. | Indiana | SR | WR | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 3 | Tarheeb Still | Maryland | SO | DB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |