2021 Big Ten Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Riley Moss | Iowa | SR | DB | 9 | 4 | 85 | 2 | 0.44 |
| 1 | Cal Haladay | Mich St | FR | LB | 11 | 2 | 108 | 2 | 0.18 |
| 3 | Ji'Ayir Brown | Penn State | SR | S | 11 | 5 | 97 | 1 | 0.45 |
| 3 | Caesar Williams | Wisconsin | SR | CB | 10 | 3 | 49 | 1 | 0.30 |
| 3 | Craig Young | Ohio State | SO | SAF | 10 | 2 | 88 | 1 | 0.20 |
| 3 | Jalen Graham | Purdue | JR | LB | 11 | 2 | 45 | 1 | 0.18 |
| 3 | DJ Turner | Michigan | JR | DB | 12 | 2 | 65 | 1 | 0.17 |
| 3 | Jack Campbell | Iowa | JR | LB | 12 | 2 | 33 | 1 | 0.17 |
| 3 | Scott Nelson | Wisconsin | SR | S | 10 | 1 | 25 | 1 | 0.10 |
| 3 | Denzel Burke | Ohio State | FR | CB | 11 | 1 | 23 | 1 | 0.09 |
| 3 | Daequan Hardy | Penn State | SO | CB | 11 | 1 | 17 | 1 | 0.09 |