2021 Big Ten Conference Leaders Interceptions - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ronnie Hickman | Ohio State | SO | SAF | 2 | 2 | 65 | 1 | 1.00 |
| 1 | Max Melton | Rutgers | FR | DB | 1 | 1 | 46 | 1 | 1.00 |
| 1 | Brandon Joseph | N'western | SO | SAF | 1 | 1 | 26 | 0 | 1.00 |
| 1 | Luke Reimer | Nebraska | SO | ILB | 1 | 1 | 22 | 0 | 1.00 |
| 1 | Tre Avery | Rutgers | SR | DB | 1 | 1 | 21 | 0 | 1.00 |
| 1 | Jesse Luketa | Penn State | SR | DE | 1 | 1 | 16 | 1 | 1.00 |
| 1 | Bryce Jackson | N'western | SR | DB | 1 | 1 | 0 | 0 | 1.00 |
| 1 | Daequan Hardy | Penn State | SO | CB | 1 | 1 | -1 | 0 | 1.00 |
| 9 | Cameron Martinez | Ohio State | FR | SAF | 2 | 1 | 61 | 1 | 0.50 |
| 9 | Gemon Green | Michigan | SR | DB | 2 | 1 | 27 | 0 | 0.50 |
| 9 | Cody Simon | Ohio State | SO | LB | 2 | 1 | 24 | 0 | 0.50 |
| 9 | Tyler Nubin | Minnesota | JR | DB | 2 | 1 | 18 | 0 | 0.50 |
| 9 | Mariano Sori-Marin | Minnesota | SR | LB | 2 | 1 | 10 | 0 | 0.50 |
| 9 | Keith Randolph Jr. | Illinois | FR | DL | 2 | 1 | 2 | 0 | 0.50 |
| 9 | Marcelino McCrary-Ball | Indiana | SR | DB | 2 | 1 | 0 | 0 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.