2021 Big Ten Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Minnesota | 4 | 103 | 173 | 1.68 | 4 | 25.75 | 43.25 |
| 2 | Wisconsin | 4 | 133 | 258 | 1.94 | 3 | 33.25 | 64.50 |
| 3 | Indiana | 3 | 78 | 276 | 3.54 | 4 | 26.00 | 92.00 |
| 4 | Iowa | 4 | 163 | 383 | 2.35 | 3 | 40.75 | 95.75 |
| 5 | Maryland | 4 | 136 | 386 | 2.84 | 3 | 34.00 | 96.50 |
| 6 | Michigan State | 4 | 127 | 395 | 3.11 | 3 | 31.75 | 98.75 |
| 7 | Rutgers | 4 | 137 | 487 | 3.55 | 4 | 34.25 | 121.75 |
| 8 | Michigan | 4 | 135 | 527 | 3.90 | 1 | 33.75 | 131.75 |
| 9 | Northwestern | 3 | 106 | 421 | 3.97 | 3 | 35.33 | 140.33 |
| 10 | Illinois | 3 | 109 | 431 | 3.95 | 4 | 36.33 | 143.67 |
| 11 | Purdue | 4 | 156 | 593 | 3.80 | 5 | 39.00 | 148.25 |
| 12 | Nebraska | 3 | 96 | 458 | 4.77 | 2 | 32.00 | 152.67 |
| 13 | Ohio State | 4 | 150 | 644 | 4.29 | 5 | 37.50 | 161.00 |
| 14 | Penn State | 4 | 150 | 662 | 4.41 | 6 | 37.50 | 165.50 |