2021 Big Ten Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Nebraska | 7 | 1018 | 1394 | 477 | 2412 | 5.06 | 344.6 |
| 2 | Indiana | 7 | 1026 | 1757 | 485 | 2783 | 5.74 | 397.6 |
| 3 | Wisconsin | 10 | 654 | 1642 | 548 | 2296 | 4.19 | 229.6 |
| 4 | Penn State | 8 | 1048 | 1515 | 596 | 2563 | 4.30 | 320.4 |
| 5 | Purdue | 9 | 1394 | 1658 | 597 | 3052 | 5.11 | 339.1 |
| 6 | Rutgers | 9 | 1376 | 1915 | 607 | 3291 | 5.42 | 365.7 |
| 7 | Maryland | 9 | 1356 | 1880 | 610 | 3236 | 5.30 | 359.6 |
| 8 | Northwestern | 9 | 1754 | 2074 | 620 | 3828 | 6.17 | 425.3 |
| 9 | Minnesota | 11 | 996 | 1856 | 648 | 2852 | 4.40 | 259.3 |
| 9 | Ohio State | 9 | 790 | 2375 | 648 | 3165 | 4.88 | 351.7 |
| 11 | Michigan | 10 | 1213 | 1766 | 657 | 2979 | 4.53 | 297.9 |
| 12 | Illinois | 11 | 1650 | 2499 | 770 | 4149 | 5.39 | 377.2 |
| 13 | Michigan State | 10 | 1055 | 3197 | 802 | 4252 | 5.30 | 425.2 |
| 14 | Iowa | 12 | 1270 | 2520 | 839 | 3790 | 4.52 | 315.8 |