2021 Big Ten Conference Leaders Rushing Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Michigan | 4 | 136 | 745 | 5.48 | 10 | 34.00 | 186.25 |
| 2 | Nebraska | 5 | 197 | 659 | 3.35 | 8 | 39.40 | 131.80 |
| 3 | Michigan State | 3 | 93 | 321 | 3.45 | 5 | 31.00 | 107.00 |
| 4 | Ohio State | 4 | 124 | 508 | 4.10 | 4 | 31.00 | 127.00 |
| 4 | Penn State | 5 | 158 | 435 | 2.75 | 4 | 31.60 | 87.00 |
| 6 | Minnesota | 2 | 100 | 392 | 3.92 | 3 | 50.00 | 196.00 |
| 6 | Indiana | 5 | 176 | 504 | 2.86 | 3 | 35.20 | 100.80 |
| 8 | Maryland | 4 | 122 | 435 | 3.57 | 2 | 30.50 | 108.75 |
| 8 | Wisconsin | 3 | 108 | 287 | 2.66 | 2 | 36.00 | 95.67 |
| 8 | Purdue | 4 | 108 | 292 | 2.70 | 2 | 27.00 | 73.00 |
| 11 | Iowa | 2 | 63 | 277 | 4.40 | 1 | 31.50 | 138.50 |
| 11 | Rutgers | 4 | 138 | 529 | 3.83 | 1 | 34.50 | 132.25 |
| 11 | Northwestern | 3 | 92 | 310 | 3.37 | 1 | 30.67 | 103.33 |
| 14 | Illinois | 1 | 25 | 64 | 2.56 | 0 | 25.00 | 64.00 |