2021 Big Ten Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Ohio State | 4 | 508 | 1900 | 317 | 2408 | 7.60 | 602.0 |
| 2 | Michigan | 4 | 745 | 1083 | 268 | 1828 | 6.82 | 457.0 |
| 3 | Purdue | 4 | 292 | 1591 | 311 | 1883 | 6.05 | 470.8 |
| 4 | Nebraska | 5 | 659 | 1274 | 339 | 1933 | 5.70 | 386.6 |
| 5 | Minnesota | 2 | 392 | 425 | 158 | 817 | 5.17 | 408.5 |
| 6 | Illinois | 1 | 64 | 248 | 61 | 312 | 5.11 | 312.0 |
| 7 | Maryland | 4 | 435 | 981 | 279 | 1416 | 5.08 | 354.0 |
| 8 | Iowa | 2 | 277 | 386 | 131 | 663 | 5.06 | 331.5 |
| 9 | Michigan State | 3 | 321 | 708 | 211 | 1029 | 4.88 | 343.0 |
| 10 | Rutgers | 4 | 529 | 822 | 283 | 1351 | 4.77 | 337.8 |
| 11 | Northwestern | 3 | 310 | 686 | 211 | 996 | 4.72 | 332.0 |
| 12 | Penn State | 5 | 435 | 1275 | 369 | 1710 | 4.63 | 342.0 |
| 13 | Wisconsin | 3 | 287 | 511 | 194 | 798 | 4.11 | 266.0 |
| 14 | Indiana | 5 | 504 | 736 | 343 | 1240 | 3.62 | 248.0 |