2021 Big Ten Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Ohio State | 9 | 11 | 286 | 4 | 1.22 |
| 2 | Iowa | 12 | 22 | 224 | 3 | 1.83 |
| 3 | Wisconsin | 10 | 15 | 233 | 2 | 1.50 |
| 3 | Penn State | 8 | 10 | 171 | 2 | 1.25 |
| 5 | Purdue | 9 | 8 | 98 | 1 | 0.89 |
| 5 | Michigan State | 10 | 7 | 137 | 1 | 0.70 |
| 5 | Rutgers | 9 | 6 | 88 | 1 | 0.67 |
| 5 | Michigan | 10 | 5 | 95 | 1 | 0.50 |
| 9 | Illinois | 11 | 8 | 39 | 0 | 0.73 |
| 9 | Minnesota | 11 | 7 | 76 | 0 | 0.64 |
| 9 | Nebraska | 7 | 6 | 33 | 0 | 0.86 |
| 9 | Northwestern | 9 | 6 | 29 | 0 | 0.67 |
| 9 | Maryland | 9 | 5 | 9 | 0 | 0.56 |
| 9 | Indiana | 7 | 1 | 23 | 0 | 0.14 |