2021 Big Ten Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Iowa | 12 | 25 | 41 | 66 | 5.50 |
| 2 | Ohio State | 11 | 8 | 48 | 56 | 5.09 |
| 3 | Penn State | 11 | 11 | 41 | 52 | 4.73 |
| 3 | Michigan State | 11 | 9 | 43 | 52 | 4.73 |
| 5 | Wisconsin | 10 | 15 | 31 | 46 | 4.60 |
| 6 | Purdue | 11 | 12 | 38 | 50 | 4.55 |
| 7 | Michigan | 12 | 7 | 47 | 54 | 4.50 |
| 8 | Illinois | 10 | 8 | 36 | 44 | 4.40 |
| 9 | Nebraska | 10 | 6 | 36 | 42 | 4.20 |
| 10 | Maryland | 11 | 5 | 41 | 46 | 4.18 |
| 11 | Rutgers | 11 | 5 | 36 | 41 | 3.73 |
| 12 | Indiana | 9 | 4 | 29 | 33 | 3.67 |
| 13 | Minnesota | 11 | 6 | 31 | 37 | 3.36 |
| 14 | Northwestern | 10 | 4 | 29 | 33 | 3.30 |