2021 Mid-American Conference Leaders Scoring Defense - Games in August/September Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 4 | 6 | 11 | 5 | 1 | 0 | 76 | 19.0 |
| 2 | Bowling Green | 4 | 9 | 6 | 8 | 0 | 0 | 80 | 20.0 |
| 3 | Western Michigan | 4 | 12 | 3 | 10 | 0 | 0 | 91 | 22.8 |
| 4 | Buffalo | 4 | 14 | 0 | 13 | 0 | 0 | 97 | 24.3 |
| 5 | Eastern Michigan | 4 | 13 | 2 | 12 | 1 | 0 | 98 | 24.5 |
| 6 | Central Michigan | 4 | 15 | 2 | 14 | 0 | 0 | 110 | 27.5 |
| 6 | Miami (Ohio) | 4 | 15 | 2 | 14 | 0 | 0 | 110 | 27.5 |
| 8 | Kent State | 4 | 15 | 4 | 14 | 0 | 1 | 118 | 29.5 |
| 9 | Ball State | 4 | 16 | 6 | 16 | 0 | 1 | 132 | 33.0 |
| 10 | Ohio | 4 | 16 | 8 | 15 | 1 | 2 | 141 | 35.3 |
| 11 | Northern Illinois | 4 | 21 | 0 | 20 | 1 | 0 | 148 | 37.0 |
| 12 | Akron | 4 | 24 | 3 | 23 | 0 | 1 | 178 | 44.5 |