2021 Mid-American Conference Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 4 | 391 | 1107 | 239 | 1498 | 6.27 | 374.5 |
| 2 | Western Michigan | 4 | 498 | 719 | 219 | 1217 | 5.56 | 304.3 |
| 3 | Toledo | 4 | 610 | 751 | 284 | 1361 | 4.79 | 340.3 |
| 4 | Buffalo | 4 | 667 | 828 | 257 | 1495 | 5.82 | 373.8 |
| 5 | Bowling Green | 4 | 696 | 592 | 289 | 1288 | 4.46 | 322.0 |
| 6 | Ball State | 4 | 759 | 993 | 272 | 1752 | 6.44 | 438.0 |
| 6 | Akron | 4 | 759 | 1054 | 233 | 1813 | 7.78 | 453.3 |
| 8 | Eastern Michigan | 4 | 778 | 850 | 274 | 1628 | 5.94 | 407.0 |
| 9 | Kent State | 4 | 789 | 1034 | 293 | 1823 | 6.22 | 455.8 |
| 10 | Miami (Ohio) | 4 | 844 | 585 | 247 | 1429 | 5.79 | 357.3 |
| 11 | Northern Illinois | 4 | 960 | 760 | 267 | 1720 | 6.44 | 430.0 |
| 12 | Ohio | 4 | 1134 | 634 | 295 | 1768 | 5.99 | 442.0 |