2021 Mid-American Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 10 | 1448 | 1763 | 578 | 3211 | 5.56 | 321.1 |
| 2 | Akron | 9 | 2405 | 1823 | 607 | 4228 | 6.97 | 469.8 |
| 3 | Bowling Green | 9 | 1672 | 1899 | 644 | 3571 | 5.55 | 396.8 |
| 4 | Buffalo | 10 | 2101 | 2276 | 676 | 4377 | 6.47 | 437.7 |
| 5 | Toledo | 12 | 1822 | 2449 | 872 | 4271 | 4.90 | 355.9 |
| 6 | Central Michigan | 9 | 1189 | 2483 | 654 | 3672 | 5.61 | 408.0 |
| 7 | Ohio | 9 | 1492 | 2489 | 653 | 3981 | 6.10 | 442.3 |
| 8 | Ball State | 11 | 1983 | 2490 | 780 | 4473 | 5.73 | 406.6 |
| 9 | Miami (Ohio) | 11 | 1684 | 2603 | 743 | 4287 | 5.77 | 389.7 |
| 10 | Kent State | 10 | 2093 | 2690 | 773 | 4783 | 6.19 | 478.3 |
| 11 | Eastern Michigan | 11 | 2142 | 2717 | 763 | 4859 | 6.37 | 441.7 |
| 12 | Northern Illinois | 11 | 2234 | 2776 | 726 | 5010 | 6.90 | 455.5 |