2021 Mid-American Conference Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 2 | 11 | 27 | 6 | 44 | 22.0 |
| 2 | Kent State | 3 | 28 | 25 | 10 | 63 | 21.0 |
| 2 | Ball State | 1 | 5 | 12 | 4 | 21 | 21.0 |
| 4 | Central Michigan | 3 | 21 | 34 | 5 | 60 | 20.0 |
| 4 | Miami (Ohio) | 1 | 6 | 12 | 2 | 20 | 20.0 |
| 6 | Buffalo | 1 | 6 | 11 | 2 | 19 | 19.0 |
| 7 | Ohio | 2 | 17 | 18 | 2 | 37 | 18.5 |
| 8 | Akron | 2 | 7 | 18 | 4 | 29 | 14.5 |
| 9 | Northern Illinois | 2 | 15 | 9 | 2 | 26 | 13.0 |
| 10 | Bowling Green | 2 | 5 | 14 | 4 | 23 | 11.5 |
| 11 | Eastern Michigan | 1 | 0 | 2 | 1 | 3 | 3.0 |