2021 Mid-American Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Central Michigan | 9 | 33.0 | 220 | 3.67 |
| 2 | Western Michigan | 10 | 35.0 | 230 | 3.50 |
| 3 | Toledo | 12 | 38.0 | 231 | 3.17 |
| 4 | Buffalo | 10 | 31.0 | 210 | 3.10 |
| 5 | Miami (Ohio) | 11 | 33.0 | 218 | 3.00 |
| 6 | Bowling Green | 9 | 18.0 | 107 | 2.00 |
| 7 | Kent State | 10 | 18.0 | 137 | 1.80 |
| 8 | Eastern Michigan | 11 | 19.0 | 132 | 1.73 |
| 9 | Ohio | 9 | 15.0 | 104 | 1.67 |
| 10 | Ball State | 11 | 18.0 | 109 | 1.64 |
| 11 | Northern Illinois | 11 | 15.0 | 101 | 1.36 |
| 12 | Akron | 9 | 10.0 | 73 | 1.11 |