2021 Pac-12 Conference Leaders Long All Purpose Plays - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Kazmeir Allen | UCLA | JR | RB | 10 | 8 | 6 | 4 | 3 | 2 | 1 | 1 |
| 1 | Kyle Philips | UCLA | JR | WR | 9 | 6 | 6 | 3 | 2 | 2 | 1 | 0 |
| 3 | Drake Anderson | Arizona | SO | RB | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Christopher Brooks | California | SR | RB | 11 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Trevon Clark | California | SR | WR | 11 | 7 | 3 | 3 | 2 | 1 | 1 | 0 |
| 3 | Tayvian Cunningham | Arizona | SR | WR | 6 | 4 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Marcel Dancy | California | SR | RB | 11 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Greg Dulcich | UCLA | JR | TE | 10 | 6 | 2 | 2 | 1 | 1 | 0 | 0 |
| 3 | Calvin Jackson Jr. | Wash St | SR | WR | 9 | 9 | 4 | 1 | 1 | 1 | 0 | 0 |
| 3 | Jack Jones | Ariz St | SR | DB | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Nathaniel Peat | Stanford | JR | RB | 9 | 6 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | TJ Pledger | Utah | JR | RB | 9 | 5 | 3 | 2 | 1 | 1 | 1 | 1 |
| 3 | Nikko Remigio | California | SR | WR | 10 | 4 | 3 | 3 | 2 | 1 | 1 | 1 |
| 3 | Bralen Trice | Washington | FR | OLB | 10 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |