2021 Pac-12 Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | California | 1 | 210 | 244 | 63 | 454 | 7.21 | 454.0 |
| 2 | UCLA | 2 | 411 | 475 | 134 | 886 | 6.61 | 443.0 |
| 3 | Arizona State | 2 | 352 | 464 | 136 | 816 | 6.00 | 408.0 |
| 4 | Colorado | 2 | 521 | 491 | 140 | 1012 | 7.23 | 506.0 |
| 5 | Washington | 2 | 672 | 142 | 147 | 814 | 5.54 | 407.0 |
| 6 | USC | 3 | 517 | 795 | 208 | 1312 | 6.31 | 437.3 |
| 7 | Stanford | 3 | 838 | 667 | 219 | 1505 | 6.87 | 501.7 |
| 8 | Oregon State | 3 | 529 | 815 | 221 | 1344 | 6.08 | 448.0 |
| 9 | Arizona | 4 | 777 | 890 | 261 | 1667 | 6.39 | 416.8 |
| 10 | Washington State | 4 | 985 | 638 | 276 | 1623 | 5.88 | 405.8 |
| 11 | Oregon | 4 | 849 | 1074 | 287 | 1923 | 6.70 | 480.8 |
| 12 | Utah | 5 | 682 | 1144 | 318 | 1826 | 5.74 | 365.2 |