2021 Pac-12 Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Washington | 10 | 2146 | 1390 | 677 | 3536 | 5.22 | 353.6 |
| 2 | Arizona | 9 | 1608 | 1799 | 559 | 3407 | 6.09 | 378.6 |
| 3 | Washington State | 9 | 1384 | 1925 | 588 | 3309 | 5.63 | 367.7 |
| 4 | California | 10 | 1521 | 2034 | 687 | 3555 | 5.17 | 355.5 |
| 5 | Arizona State | 10 | 1399 | 2103 | 678 | 3502 | 5.17 | 350.2 |
| 6 | USC | 9 | 1579 | 2105 | 557 | 3684 | 6.61 | 409.3 |
| 7 | Stanford | 11 | 2659 | 2238 | 763 | 4897 | 6.42 | 445.2 |
| 8 | UCLA | 10 | 1351 | 2424 | 677 | 3775 | 5.58 | 377.5 |
| 9 | Oregon State | 10 | 1561 | 2443 | 670 | 4004 | 5.98 | 400.4 |
| 10 | Colorado | 11 | 2122 | 2672 | 774 | 4794 | 6.19 | 435.8 |
| 11 | Utah | 11 | 1213 | 2706 | 710 | 3919 | 5.52 | 356.3 |
| 12 | Oregon | 12 | 1788 | 2951 | 854 | 4739 | 5.55 | 394.9 |