2021 Pac-12 Conference Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Utah | 5 | 46 | 46 | 14 | 106 | 21.2 |
| 2 | Arizona | 4 | 29 | 42 | 12 | 83 | 20.8 |
| 3 | Oregon | 4 | 40 | 38 | 7 | 85 | 21.3 |
| 3 | Washington State | 4 | 27 | 48 | 7 | 82 | 20.5 |
| 5 | UCLA | 2 | 20 | 26 | 6 | 52 | 26.0 |
| 5 | Stanford | 3 | 16 | 23 | 6 | 45 | 15.0 |
| 7 | Oregon State | 3 | 28 | 35 | 4 | 67 | 22.3 |
| 8 | Washington | 2 | 7 | 16 | 3 | 26 | 13.0 |
| 9 | USC | 3 | 30 | 47 | 2 | 79 | 26.3 |
| 10 | California | 1 | 10 | 12 | 1 | 23 | 23.0 |
| 10 | Colorado | 2 | 14 | 13 | 1 | 28 | 14.0 |
| 12 | Arizona State | 2 | 17 | 23 | 0 | 40 | 20.0 |