2021 Independent Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 4 | 402 | 605 | 240 | 1007 | 4.20 | 251.8 |
| 2 | Army | 4 | 234 | 877 | 199 | 1111 | 5.58 | 277.8 |
| 3 | Notre Dame | 4 | 523 | 938 | 285 | 1461 | 5.13 | 365.3 |
| 4 | BYU | 4 | 609 | 943 | 268 | 1552 | 5.79 | 388.0 |
| 5 | New Mexico State | 5 | 935 | 1336 | 339 | 2271 | 6.70 | 454.2 |
| 6 | Connecticut | 5 | 1152 | 1167 | 367 | 2319 | 6.32 | 463.8 |
| 7 | Massachusetts | 4 | 969 | 1165 | 285 | 2134 | 7.49 | 533.5 |