2021 National Leaders Long All Purpose Plays - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Britain Covey | Utah | JR | WR | 5 | 6 | 3 | 3 | 3 | 3 | 2 | 1 |
| 2 | Brian Battie | S Florida | SO | RB | 4 | 3 | 2 | 2 | 2 | 2 | 2 | 2 |
| 2 | Brian Brewton | UConn | FR | RB | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 |
| 2 | Zonovan Knight | NC State | SO | RB | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 |
| 2 | Malik Knowles | Kansas St | JR | WR | 3 | 3 | 3 | 2 | 2 | 2 | 2 | 2 |
| 2 | Jameson Williams | Alabama | JR | WR | 5 | 6 | 5 | 3 | 2 | 1 | 0 | 0 |
| 2 | Xavier Worthy | Texas | FR | WR | 5 | 6 | 3 | 2 | 2 | 1 | 0 | 0 |
| 8 | Devon Achane | Texas A&M | SO | RB | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Anthony Adkins | Army | SO | RB | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Rasheen Ali | Marshall | FR | RB | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Tyler Allgeier | BYU | SO | RB | 3 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | Andrel Anthony | Michigan | FR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Chris Autman-Bell | Minnesota | SR | WR | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Taye Barber | TCU | SR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | B.J. Baylor | Oregon St | JR | RB | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | David Bell | Purdue | JR | WR | 4 | 6 | 5 | 3 | 1 | 0 | 0 | 0 |
| 8 | Max Borghi | Wash St | SR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Gary Bryant Jr. | USC | SO | WR | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Treylon Burks | Arkansas | JR | WR | 3 | 4 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Jordan Byrd | SDSU | SR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | James Cook | Georgia | SR | RB | 6 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | Jashaun Corbin | FSU | SO | RB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Blake Corum | Michigan | SO | RB | 4 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | Aron Cruickshank | Rutgers | JR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Derius Davis | TCU | SR | WR | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Ja’Khi Douglas | FSU | FR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Dontario Drummond | Miss | SR | WR | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Robert Floyd | CSU | FR | DB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Eugene Ford | Hawai'i | SR | DB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Jerome Ford | Cincinnati | JR | RB | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Jahmyr Gibbs | Ga Tech | FR | RB | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Antoine Green | N Carolina | SR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Gerald Green | Ga South | SO | RB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Lideatrick Griffin | Miss St | SO | WR | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Cal Haladay | Mich St | FR | LB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Tyler Harrell | Louisville | SO | WR | 5 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Jimmy Horn Jr. | S Florida | FR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Evan Hull | N'western | SO | RB | 3 | 4 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Te'Vailance Hunt | Ark St | JR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Calvin Jackson Jr. | Wash St | SR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Steve Jenkins | UNLV | JR | WR | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Quentin Johnston | TCU | SO | WR | 3 | 4 | 2 | 2 | 1 | 1 | 0 | 0 |
| 8 | Velus Jones Jr. | Tennessee | SR | WR | 5 | 6 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Josh Kelly | Fresno St | SO | WR | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Bryant Koback | Toledo | JR | RB | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Travis Koontz | Texas Tech | SR | TE | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Cameron Latu | Alabama | JR | TE | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Devin Maddox | Toledo | SO | WR | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Bryan Massey | SMU | SO | S | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | DeWayne McBride | UAB | SO | RB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | JaVonta Payton | Tennessee | SR | WR | 5 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 8 | Trebor Pena | Syracuse | FR | WR | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Brennan Presley | Okla St | SO | WR | 4 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 8 | Charleston Rambo | Miami (Fl) | JR | WR | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Nikko Reed | Colorado | FR | CB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Kelee Ringo | Georgia | FR | DB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Cameron Rising | Utah | SO | QB | 4 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 8 | Demetris Robertson | Auburn | SR | WR | 5 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Merlin Robertson | Ariz St | SR | LB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Braylon Sanders | Miss | SR | WR | 3 | 4 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | Khalil Shakir | Boise St | SR | WR | 4 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Abram Smith | Baylor | SR | RB | 5 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 8 | Christopher Smith | Georgia | SR | DB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Isaiah Spiller | Texas A&M | JR | RB | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Jaylen Stinson | Duke | SO | S | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Cameron Stone | Wyoming | SO | CB | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Titus Swen | Wyoming | JR | RB | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Keondre Swoopes | UAB | JR | S | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Dont'e Thornton | Oregon | FR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Cedric Tillman | Tennessee | JR | WR | 5 | 5 | 3 | 3 | 1 | 1 | 0 | 0 |
| 8 | Mitchell Tinsley | Western Ky | JR | WR | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Lawrance Toafili | FSU | FR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Jalen Tolbert | USA | JR | WR | 1 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 8 | Justin Tomlin | Ga South | JR | QB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Samori Toure | Nebraska | SR | WR | 5 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 8 | Josh Vann | S Carolina | SR | WR | 3 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Deuce Vaughn | Kansas St | SO | RB | 3 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | CJ Verdell | Oregon | JR | RB | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Al Walcott | Baylor | JR | CB | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Jordan Watkins | Louisville | FR | WR | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Dontayvion Wicks | Virginia | SO | WR | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Charles Williams | UNLV | SR | RB | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Christian Williams | S Florida | SO | S | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Garrett Wilson | Ohio State | JR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Ontaria Wilson | FSU | JR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Roman Wilson | Michigan | SO | WR | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | A.J. Woods | Pittsburgh | JR | DB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |