2022 Conference USA Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Reginald Johnson Jr. | La Tech | SO | DB | 2 | 0 | 4 | 4 | 2.00 |
| 1 | Kahlef Hailassie | Western Ky | JR | DB | 2 | 0 | 4 | 4 | 2.00 |
| 3 | Decorian Patterson | MTSU | JR | CB | 1 | 1 | 2 | 3 | 3.00 |
| 3 | Starling Thomas V | UAB | SR | CB | 1 | 0 | 2 | 2 | 2.00 |
| 3 | JaQues Evans | Western Ky | SO | LB | 2 | 0 | 2 | 2 | 1.00 |
| 3 | Davion Williams | Western Ky | JR | DB | 2 | 0 | 2 | 2 | 1.00 |
| 7 | Wayne Jones | Charlotte | JR | DB | 2 | 1 | 1 | 2 | 1.00 |
| 7 | Drew Tuazama | UAB | JR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Justin McKithen | FAU | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Teldrick Ross | MTSU | JR | S | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Jordan Ferguson | MTSU | SR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Tra Fluellen | MTSU | JR | S | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Deidrick Stanley II | MTSU | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Jadrian Taylor | UTEP | SR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Latrez Shelton | UTEP | SO | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Dennis Barnes | UTEP | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Corey Mayfield Jr. | UTSA | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 7 | Willie Roberts | La Tech | JR | DB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Myles Brooks | La Tech | JR | DB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Tyler Grubbs | La Tech | SO | LB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Khiry Morrison | La Tech | SO | LB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Dominique Bradshaw | Western Ky | SR | DB | 2 | 0 | 1 | 1 | 0.50 |
| 7 | Will Ignont | Western Ky | SR | LB | 2 | 0 | 1 | 1 | 0.50 |