2022 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 5 | 427 | 1308 | 369 | 1735 | 4.70 | 347.0 |
| 2 | Western Kentucky | 6 | 802 | 1571 | 457 | 2373 | 5.19 | 395.5 |
| 3 | UTEP | 4 | 718 | 548 | 243 | 1266 | 5.21 | 316.5 |
| 4 | UAB | 5 | 879 | 1004 | 356 | 1883 | 5.29 | 376.6 |
| 5 | UTSA | 5 | 894 | 1013 | 357 | 1907 | 5.34 | 381.4 |
| 6 | Florida International | 4 | 724 | 821 | 275 | 1545 | 5.62 | 386.3 |
| 7 | Florida Atlantic | 4 | 677 | 1052 | 289 | 1729 | 5.98 | 432.3 |
| 8 | Louisiana Tech | 4 | 922 | 851 | 282 | 1773 | 6.29 | 443.3 |
| 9 | North Texas | 5 | 1245 | 1154 | 365 | 2399 | 6.57 | 479.8 |
| 10 | Rice | 5 | 980 | 973 | 267 | 1953 | 7.31 | 390.6 |
| 11 | Charlotte | 4 | 1050 | 1268 | 283 | 2318 | 8.19 | 579.5 |