2022 Conference USA Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 18 | 27 | 4 | 49 | 24.5 |
| 2 | Charlotte | 2 | 13 | 25 | 7 | 45 | 22.5 |
| 3 | Louisiana Tech | 2 | 5 | 23 | 5 | 33 | 16.5 |
| 4 | UTEP | 1 | 4 | 19 | 3 | 26 | 26.0 |
| 5 | UTSA | 1 | 10 | 15 | 4 | 29 | 29.0 |
| 6 | Florida Atlantic | 1 | 10 | 8 | 3 | 21 | 21.0 |
| 6 | Middle Tennessee | 1 | 6 | 8 | 0 | 14 | 14.0 |
| 6 | UAB | 1 | 3 | 8 | 1 | 12 | 12.0 |
| 9 | Rice | 1 | 6 | 7 | 1 | 14 | 14.0 |