2022 Big 12 Conference Leaders Long All Purpose Plays - Games vs. Conference Teams Only through 01/09/2023
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Taye Barber | TCU | SR | WR | 10 | 4 | 3 | 3 | 3 | 3 | 0 | 0 |
| 2 | Monaray Baldwin | Baylor | SO | WR | 8 | 3 | 3 | 2 | 2 | 2 | 0 | 0 |
| 3 | Jason Bean | Kansas | SR | QB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Jonathon Brooks | Texas | FR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Phillip Brooks | Kansas St | SR | WR | 10 | 5 | 2 | 1 | 1 | 1 | 1 | 0 |
| 3 | Cobee Bryant | Kansas | SO | CB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Derius Davis | TCU | SR | WR | 9 | 4 | 3 | 3 | 2 | 1 | 1 | 0 |
| 3 | Sam James | WVU | JR | WR | 9 | 6 | 3 | 2 | 1 | 1 | 0 | 0 |
| 3 | Kendre Miller | TCU | JR | RB | 10 | 5 | 5 | 4 | 2 | 1 | 0 | 0 |
| 3 | Marvin Mims Jr. | Oklahoma | JR | WR | 9 | 9 | 4 | 4 | 3 | 1 | 0 | 0 |
| 3 | Jaden Nixon | Okla St | FR | RB | 9 | 4 | 2 | 2 | 1 | 1 | 1 | 1 |
| 3 | John Paul Richardson | Okla St | SO | WR | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Deuce Vaughn | Kansas St | JR | RB | 10 | 6 | 5 | 3 | 3 | 1 | 1 | 0 |
| 3 | Brayden Willis | Oklahoma | SR | TE | 9 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |