2022 Big 12 Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Jason Taylor II | Okla St | SR | S | 3 | 2 | 16 | 0 | 0.67 |
| 1 | Malachi Ruffin | WVU | JR | DB | 4 | 2 | 43 | 1 | 0.50 |
| 1 | Bud Clark | TCU | SO | S | 5 | 2 | 46 | 1 | 0.40 |
| 1 | Tre'Vius Hodges-Tomlinson | TCU | SR | CB | 5 | 2 | 20 | 0 | 0.40 |
| 5 | Devin Neal | Baylor | JR | S | 2 | 1 | 0 | 0 | 0.50 |
| 5 | Reggie Pearson Jr. | Texas Tech | SR | DB | 3 | 1 | 25 | 0 | 0.33 |
| 5 | C.J. Coldon | Oklahoma | SR | DB | 3 | 1 | 20 | 0 | 0.33 |
| 5 | Kendal Daniels | Okla St | FR | S | 3 | 1 | 8 | 0 | 0.33 |
| 5 | Kobe Savage | Kansas St | JR | S | 3 | 1 | 0 | 0 | 0.33 |
| 5 | O.J. Burroughs | Kansas | SO | S | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Billy Bowman Jr. | Oklahoma | SO | DB | 3 | 1 | 0 | 0 | 0.33 |
| 5 | Jaylan Ford | Texas | JR | LB | 4 | 1 | 18 | 0 | 0.25 |
| 5 | Jerrin Thompson | Texas | JR | DB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Daniel Green | Kansas St | SR | LB | 5 | 1 | 49 | 0 | 0.20 |
| 5 | Dee Winters | TCU | SR | LB | 5 | 1 | 29 | 1 | 0.20 |
| 5 | Julius Brents | Kansas St | SR | CB | 5 | 1 | 0 | 0 | 0.20 |