2022 Big 12 Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bud Clark | TCU | SO | S | 12 | 5 | 83 | 1 | 0.42 |
| 1 | Cobee Bryant | Kansas | SO | CB | 10 | 3 | 86 | 1 | 0.30 |
| 1 | Cincere Mason | Kansas St | SR | S | 9 | 2 | 37 | 1 | 0.22 |
| 1 | Malachi Ruffin | WVU | JR | DB | 11 | 2 | 43 | 1 | 0.18 |
| 1 | Jacolby Spells | WVU | FR | DB | 7 | 1 | 27 | 1 | 0.14 |
| 1 | AJ McCarty | Baylor | SO | CB | 9 | 1 | 18 | 1 | 0.11 |
| 1 | Millard Bradford | TCU | SR | S | 11 | 1 | 36 | 1 | 0.09 |
| 1 | Josh Newton | TCU | JR | CB | 13 | 1 | 57 | 1 | 0.08 |
| 1 | Dee Winters | TCU | SR | LB | 13 | 1 | 29 | 1 | 0.08 |