2022 Big 12 Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 24 | 209 | 62 | 233 | 3.76 | 233.0 |
| 2 | Texas Tech | 1 | 87 | 266 | 68 | 353 | 5.19 | 353.0 |
| 3 | TCU | 1 | 104 | 372 | 86 | 476 | 5.53 | 476.0 |
| 4 | Oklahoma State | 1 | 122 | 424 | 88 | 546 | 6.20 | 546.0 |
| 5 | Kansas State | 1 | 160 | 176 | 66 | 336 | 5.09 | 336.0 |
| 6 | Kansas | 1 | 174 | 272 | 70 | 446 | 6.37 | 446.0 |
| 7 | Oklahoma | 2 | 192 | 419 | 155 | 611 | 3.94 | 305.5 |
| 8 | Texas | 2 | 231 | 436 | 148 | 667 | 4.51 | 333.5 |
| 9 | Baylor | 3 | 441 | 572 | 217 | 1013 | 4.67 | 337.7 |